THE POSSIBILITY OF CORRECTION OF BLOOD INDICATORS IN EXPERIMENTAL EMPHYSEMA OF LUNGS
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Keywords

papain, pulmonary emphysema, erythrocytes, peroxide resistance, sorption capacity, ceruloplasmin

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Korzhov, V., Liskina, I., Zhadan, V., Osypenko, B., & МelnykO. (2017). THE POSSIBILITY OF CORRECTION OF BLOOD INDICATORS IN EXPERIMENTAL EMPHYSEMA OF LUNGS. Medical Science of Ukraine (MSU), 12(3-4), 11-15. Retrieved from https://msu-journal.com/index.php/journal/article/view/78

Abstract

Relevance. Disorders of biochemical mechanisms of homeostasis and their correction in emphysema of the lungs to the present have not been adequately studied.

Objective:  to study the character of changes in peroxide resistance, the sorption capacity of erythrocytes, and the content of ceruloplasmin in the blood plasma with the effect of sodium succinate to these parameters under experimental pulmonary emphysema.

Materials and methods. The model of emphysema was created on white rats by a single-dose intratracheal administration of papain. Succinate sodium was used to correct the disorders. It was studied peroxide resistance, the sorption capacity of erythrocyte membranes and the content of ceruloplasmin in the blood plasma.

Results. Three weeks after the administration of papain to animals, they developed emphysema predominantly of the panlobular type, accompanied by a 57% decrease in peroxide resistance, 31% of sorption capacity of erythrocytes, and 17% of ceruloplasmin content in blood plasma. In animals that received sodium succinate, these parameters returned to normal, blood circulation in the lung tissue was restored.

Conclusion. Sodium succinate improves the functional capacity of membranes of erythrocytes and blood plasma in lung emphysema.

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