Background. The article is devoted to an analytical review of the methods of using stem cells in the treatment of diabetes mellitus (DM).
Aim: to analyze, based on the data of the literature, the prospects of using stem cells for the treatment of DM.
Materials and methods. Review of scientific literature in the international electronic scientometric databases PubMed, Scopus, Web of Science by keywords for the period 20017-2023. The search was carried out by three independent authors. 98 sources were selected for analysis, of which 33 were used that met the search criteria.
Results. DM is a serious problem for the health care system worldwide, which requires the development of new innovative and effective therapeutic approaches. The use of stem cells is one such promising strategy for solving this problem. The ability of stem cells to differentiate into various body cells, including beta cells of the pancreas, was analyzed. Animal studies have demonstrated the ability to improve insulin synthesis and lower blood glucose levels. The use of stem cells in the treatment of DM is not a widespread approach and requires additional clinical studies. General information on the use of stem cells in the treatment of diabetes is presented and the prospects of this method of therapy are outlined.
Conclusions. The use of stem cells in the treatment of diabetes is a promising technology that may open new opportunities for the treatment of this disease. However, more research needs to be done, a number of technical, ethical, and legal issues need to be addressed, as well as regulatory standards for the production and use of stem cells.
2. Matsushita K. Heart failure and adipose mesenchymal stem cells. Trends Mol Med. 2020;26(4):369-79. DOI: 10.1016/j.molmed.2020.01.003.
3. Liu Y, Zhao X, Li J, Zhou L, Chang W, Li J, et al. MiR-155 inhibits TP53INP1 expression leading to enhanced glycolysis of psoriatic mesenchymal stem cells. J Dermatol Sci. 2022;105(3):142-51. DOI: 10.1016/j.jdermsci.2022.02.001.
4. Maacha S, Sidahmed H, Jacob S, Gentilcore G, Calzone R, Grivel J-C, et al. Paracrine mechanisms of mesenchymal stromal cells in angiogenesis. Stem Cells Int. 2020;2020:4356359. DOI: 10.1155/2020/4356359.
5. Kotelban AV. Evaluation the effectiveness of the treatment chronic catarrhal gingivitis in children with diabetes mellitus. Clinical Dentistry. 2017;(1).39-44. https://ojs.tdmu.edu.ua/index.php/kl-stomat/article/view/7535.
6. Гаращенко ОО, Коноваленко ВФ, Коноваленко СВ. Сучасні підходи до діагностики і лікування хворих на рак молочної залози. Онкологія. 2021;23(1-2):1-9. Available from: https://www.oncology.kiev.ua/article/9320/suchasni-pidxodi-do-diagnostiki-i-likuvannya-xvorix-na-rak-molochnoi-zalozi.
7. Ye L, Li L, Wan B, Yang M, Hong J, Gu W, et al. Immune response after autologous hematopoietic stem cell transplantation in type 1 diabetes mellitus. Stem Cell Res Ther. 2017;8(1). DOI: 10.1186/s13287-017-0542-1.
8. Missoum A. Recent updates on mesenchymal stem cell based therapy for acute renal failure. Curr Urol. 2020;13(4):189-99. DOI: 10.1159/000499272.
9. Godovanets O, Kitsak Т, Halchuk K, Sauka E. Odontogenic stem cells and their prospects in practical use (literature review). Bukovinian Med Her. 2021;25(4(100)):117-22. DOI: 10.24061/2413-0737.xxv.4.100.2021.20.
10. Peng B-Y, Dubey NK, Mishra VK, Tsai F-C, Dubey R, Deng W-P, et al. Addressing stem cell therapeutic approaches in pathobiology of diabetes and its complications. J Diabetes Res. 2018;2018:1-16. DOI: 10.1155/2018/7806435.
11. Motawea SM, Noreldin RI, Naguib YM. Potential therapeutic effects of endothelial cells trans-differentiated from Wharton’s Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model. Diabetol Metab Syndr. 2020;12(1):40. DOI: 10.1186/s13098-020-00546-y.
12. Zhang Y, Chen W, Feng B, Cao H. The clinical efficacy and safety of stem cell therapy for diabetes mellitus: A systematic review and meta-analysis. Aging Dis. 2020;11(1):141-3. DOI: 10.14336/AD.2019.0421.
13. Qin C, Li Y, Wang K. Functional mechanism of bone marrow-derived mesenchymal stem cells in the treatment of animal models with Alzheimer’s disease: Inhibition of neuroinflammation. J Inflamm Res. 2021;14:4761-5. DOI: 10.2147/JIR.S327538.
14. An T, Chen Y, Tu Y, Lin P. Mesenchymal stromal cell-derived extracellular vesicles in the treatment of diabetic foot ulcers: Application and challenges. Stem Cell Rev Rep. 2021;17(2):369-78. DOI: 10.1007/s12015-020-10014-9.
15. Sávio-Silva C, Soinski-Sousa PE, Simplício-Filho A, Bastos RMC, Beyerstedt S, Rangel ÉB. Therapeutic potential of mesenchymal stem cells in a pre-clinical model of diabetic kidney disease and obesity. Int J Mol Sci. 2021;22(4):1546. DOI: 10.3390/ijms22041546.
16. Sufianov A, Kostin A, Begliarzade S, Kudriashov V, Ilyasova T, Liang Y, et al. Exosomal non coding RNAs as a novel target for diabetes mellitus and its complications. Noncoding RNA Res. 2023;8(2):192-04. DOI: 10.1016/j.ncrna.2023.02.001.
17. Bhansali S, Dutta P, Yadav MK, Jain A, Mudaliar S, Hawkins M, et al. Autologous bone marrow-derived mononuclear cells transplantation in type 2 diabetes mellitus: effect on β-cell function and insulin sensitivity. Diabetol Metab Syndr. 2017;9(1). DOI: 10.1186/s13098-017-0248-7.
18. Suvakov S, Richards C, Nikolic V, Simic T, McGrath K, Krasnodembskaya A, et al. Emerging therapeutic potential of mesenchymal stem/stromal cells in preeclampsia. Curr Hypertens Rep. 2020;22(5):37. DOI: 10.1007/s11906-020-1034-8.
19. da Silva JS, Gonçalves RGJ, Vasques JF, Rocha BS, Nascimento-Carlos B, Montagnoli TL, et al. Mesenchymal stem cell therapy in diabetic cardiomyopathy. Cells. 2022;11(2):240. DOI: 10.3390/cells11020240.
20. Wang Y, Liu J, Wang H, Lv S, Liu Q, Li S, et al. Mesenchymal stem cell-derived exosomes ameliorate diabetic kidney disease through the NLRP3 signaling pathway. Stem Cells. 2023;sxad010. DOI: 10.1093/stmcls/sxad010.
21. Wu Y, Zhang C, Guo R, Wu D, Shi J, Li L, et al. Mesenchymal stem cells: An overview of their potential in cell-based therapy for diabetic nephropathy. Stem Cells Int. 2021;2021:6620811. DOI: 10.1155/2021/6620811.
22. Yan H, Ding Y, Lu M. Current status and Prospects in the treatment of Erectile Dysfunction by adipose-Derived Stem Cells in the Diabetic Animal Model. Sex Med Rev. 2020;8(3):486-91. DOI: 10.1016/j.sxmr.2019.09.006.
23. Yi S, Cong Q, Zhu Y, Xu Q. Mechanisms of action of mesenchymal stem cells in metabolic-associated fatty liver disease. Stem Cells Int. 2023;2023:3919002. DOI: 10.1155/2023/3919002.
24. Zhang L, Wang Q, Su H, Cheng J. Exosomes from adipose derived mesenchymal stem cells alleviate diabetic osteoporosis in rats through suppressing NLRP3 inflammasome activation in osteoclasts. J Biosci Bioeng. 2021;131(6):671-8. DOI: 10.1016/j.jbiosc.2021.02.007.
25. Bani Hamad FR, Rahat N, Shankar K, Tsouklidis N. Efficacy of stem cell application in diabetes mellitus: Promising future therapy for diabetes and its complications. 2021;13(2):e13563. DOI: 10.7759/cureus.13563.
26. Dama G, Du J, Zhu X, Liu Y, Lin J. Bone marrow-derived mesenchymal stem cells: A promising therapeutic option for the treatment of diabetic foot ulcers. Diabetes Res Clin Pract. 2023;195(110201):110201. DOI: 10.1016/j.diabres.2022.110201.
27. Bray ER, Kirsner RS, Badiavas EV. Mesenchymal stem cell-derived extracellular vesicles as an advanced therapy for chronic wounds. Cold Spring Harb Perspect Biol. 2022;14(10):a041227. DOI: 10.1101/cshperspect.a041227.
28. Zang L, Hao H, Liu J, Li Y, Han W, Mu Y. Mesenchymal stem cell therapy in type 2 diabetes mellitus. Diabetol Metab Syndr . 2017;9(1):36. DOI: 10.1186/s13098-017-0233-1.
29. Prudnikov IM, Tsyvkin VM, Smirnov AM, Pristash IV, et al. Human hematopoietic stem cells generate exosomes containing active proteasomes but not caspases. Fìzìol Zh. 2020;66(6):13-20. DOI: 10.15407/fz66.06.013.
30. Palomares T, Cordero M, Bruzos-Cidon C, Torrecilla M, Ugedo L, Alonso-Varona A. The neuroprotective effect of conditioned medium from human adipose-derived mesenchymal stem cells is impaired by N-acetyl cysteine supplementation. Mol Neurobiol. 2018;55(1):13-25. DOI: 10.1007/s12035-017-0714-0.
31. Afify SM, Seno M. Conversion of stem cells to cancer stem cells: Undercurrent of cancer initiation. Cancers (Basel). 2019;11(3):345. DOI: 10.3390/cancers11030345.
32. Volarevic V, Markovic BS, Gazdic M, Volarevic A, Jovicic N, Arsenijevic N, et al. Ethical and safety issues of stem cell-based therapy. Int J Med Sci. 2018;15(1):36-45. DOI: 10.7150/ijms.21666.
33. Rahim F, Arjmand B, Shirbandi K, Payab M, Larijani B. Stem cell therapy for patients with diabetes: a systematic review and meta-analysis of metabolomics-based risks and benefits. Stem Cell Investig. 2018;5:40. DOI: 10.21037/sci.2018.11.01.
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