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Abstract
Background. The spread of a new strain of SARS-CoV-2 and the pandemic that caused it has led to huge changes around the world. So, it reminded us again about the importance of developing measures for the prevention of infections that transmitted by air droplets.
Aim: investigation of the antimicrobial activity of aminomethanesulfonic acid (AMSA) and its derivatives (N-(2-hydroxyethyl)-(HEAMSA), N-benzyl-(BnAMSA) and N-(tert-butyl)-(t-BuAMSA)) which impregnated on filtering fibrous material and can be used for the manufacture of anti-aerosol elements of individual respiratory protection against strains of Staphylococcus aureus with different level of antibiotics resistance.
Materials and methods. The standard method of Kirby and Bauer disks is used for the investigation of the specific activity of antimicrobial drugs. The 24-hour cultures of microorganisms that contained (1.2+0.2)x109 CFU/ml were diluted according to the turbidity standard. The results were detected after 18-20 hours of incubation at 37°C. The 0.5 cm diameter filter fibrous discs contained the following compounds: AMSA, HEAMSA, BzAMSA, t-BuAMSA and streptocide (sulfanilamide) as a reference with active compound content (Q) at a final concentration of 0.047 and 0.236 mmol/g.
Results. All test samples with aminomethanesulfonic acids at a final concentration of 0.236 mmol/g that were applied to the filter fibrous material had a higher level of inhibition of the growth of the microorganisms than the prototype using streptocide (sulfanilamide) e against the strains of Staphylococcus aureus 2781 and Staphylococcus aureus Kunda.
Conclusions. Samples based on HEAMSA showed the greatest antimicrobial activity against the studied strains of Staphylococcus aureus from all research samples of filter fibrous material with YAMSA. They were characterized by the maximum hydrophilicity and the minimum value of the empirical pKa function lgPow. AMSA and HEAMSA were characterized by the smallest particle sizes on the surface of lavsan fiber according to electron microscopy analysis. This provides the largest boundary of contact between the phases of these biocides in the composition of the filtering fibrous material with bio aerosols during respiratory air purification.
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