CLINICAL-MORPHOMETRIC RATIO OF DEGENERATIVE-DYSTROPHIC PROCESSES OF THE CERVICAL SPINE IN HUMANS AND ANIMALS IN SPINAL CHANNEL STENOSIS
Article PDF (Українська)

Keywords

degenerative-dystrophic lesions, cervical spine, spinal canal stenosis, pain, cervicalgia

Abstract views: 39
PDF Downloads: 18

How to Cite

Andreeva , T., Stoyanov , O., Chebotaryova , G., Hruzevskyi , O., Stoianov , A., Chikur , L., & Kozishkurt , O. (2022). CLINICAL-MORPHOMETRIC RATIO OF DEGENERATIVE-DYSTROPHIC PROCESSES OF THE CERVICAL SPINE IN HUMANS AND ANIMALS IN SPINAL CHANNEL STENOSIS. Medical Science of Ukraine (MSU), 18(2), 29-38. https://doi.org/10.32345/2664-4738.2.2022.05

Abstract

Relevance. Spinal stenosis is a common manifestation of degenerative-dystrophic lesions of the cervical spine (CS). In most cases it occurs with the development of neurological complications in the form of secondary spondylogenic myelopathy, radicular dysfunction, pain. Isolated studies indicate that this type of damage occurs in some animals.

Objective: a comparative analysis of clinical, radiological and morphometric data on degenerative-dystrophic lesions in human and domestic animals on the background of degenerative changes in bone structures that provoke stenosis of the spinal canal with the development of spondylogenic myelopathy.

Material and methods. The retrospective analysis included 65 patients (25 men, 40 women) with neurological symptoms who underwent computed tomography during 2018-2021. Prospectively, a study was performed with the participation of 75 domestic animals with similar symptoms (19 dogs of large breeds weighing more 20 kg, 42 dogs of small and medium breeds weighing less 20 kg, and 14 cats.

Results. There was a close correlation of symptoms in humans and large dogs in the presence and degree of narrowing of the canal: in cases of stenosis of the ventricles in humans (75.3%), large breeds of dogs (78.9%), patients had similar neurological symptoms. The maximum decrease in the sagittal diameter of the spinal canal was found more at the level of the C6 vertebral body in both humans and animals, weighing more than 20 kg. The mass share of stenotic changes was mainly registered in men (84.0% vs. 70.0% in women). In addition, according to the Pavlov-Torg morphometric index, the width of the spinal canal in men was smaller than in women. Stenosis of the spinal canal was mainly registered in large breeds of dogs (78.9%), which almost completely coincided with the morphometry in humans (75.4%).

Conclusions. The data of our research indicate the possibility of using large breeds of dogs in predicting the course of degenerative-dystrophic changes in humans, because physiological and pathophysiological processes in dogs are on average 7 times faster than in humans. The severity of the process, the clinic and morphometric data of CS animals depend on the species, breed, weight, age, and common factors in the development of degenerative-dystrophic changes in humans and some groups of animals may be aging in general and the spine in particular.

https://doi.org/10.32345/2664-4738.2.2022.05
Article PDF (Українська)

References

Liev AA. [Vertebroneurology: formation, problems, prospects]. International Journal of Neurology. 2009; 3(25):12-18. [In Russian].

View at:

Publisher Site: http://www.mif-ua.com/archive/article/8941

Kozelkin AA, Kozelkina SA. [Modern aspects of diagnosis and treatment of vertebrogenic pain syndromes]. International Journal of Neurology. 2006; 1(5):67-72. [In Russian].

View at:

Publisher Site: http://www.mif-ua.com/archive/article/2617

Kazeminasab S, Nejadghaderi SA, Amiri P, Pourfathi H, Araj-Khodaei M, Sullman MJM, Kolahi A-A, Safiri S. Neck pain: global epidemiology, trends and risk factors. BMC Musculoskelet Disord. 2022;23(1):26. DOI:10.1186/s12891-021-04957-4

View at:

Publisher Site: https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-021-04957-4

PubMed: https://pubmed.ncbi.nlm.nih.gov/34980079/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725362/

Murray CJL, Atkinson C, Bhalla K, еt al. The state of US health, 1990-2010: burden of diseases, injuries, and risk factors. JAMA. 2013; 310(6): 591-608. DOI: 10.1001/jama.2013.13805

View at:

Publisher Site: https://jamanetwork.com/journals/jama/fullarticle/1710486

PubMed: https://pubmed.ncbi.nlm.nih.gov/23842577/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436627/

Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the global burden of disease study 2016. Lancet. 2017;390(10100):1211-59. DOI: 10.1016/S0140-6736(17)32154-2

View at:

Publisher Site: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32154-2/fulltext

PubMed: https://pubmed.ncbi.nlm.nih.gov/28919117/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605509/

Hurwitz EL, Randhawa K, Yu H, Cote P, Haldeman S. The global spine care initiative: a summary of the global burden of low back and neck pain studies. Eur Spine J. 2018;27(Suppl 6):796-801. DOI: 10.1007/s00586-017-5432-9

View at:

Publisher Site: https://link.springer.com/article/10.1007/s00586-017-5432-9

PubMed: https://pubmed.ncbi.nlm.nih.gov/29480409/

Yates K. The Math of Life and Death: 7 Mathematical Principles That Shape Our Lives Paperback. 2020. 288 p.

View at:

Publisher Site: https://www.goodreads.com/book/show/52941755-the-math-of-life-and-death

Iyer S, Kim HJ. Cervical radiculopathy. Curr Rev Musculoskelet Med. 2016;9(3):272-280. DOI:10.1007/s12178-016-9349-4

View at:

Publisher Site: https://link.springer.com/article/10.1007/s12178-016-9349-4

PubMed: https://pubmed.ncbi.nlm.nih.gov/27250042/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958381/

Ulbrich EJ, Schraner C, Boesch C, Hodler J, Busato A, Anderson SE, Eigenheer S, Zimmermann H, Sturzenegger M, Normative MR. Cervical Spinal Canal Dimensions. Radiology. 2014; 271(1): 172-182. DOI: 10.1148/radiol.13120370

View at:

Publisher Site: https://pubs.rsna.org/doi/10.1148/radiol.13120370

PubMed: https://pubmed.ncbi.nlm.nih.gov/24475792/

Pavlov H, Torg JS, Robie B, Jahre C. Cervical spinal stenosis. Determination with vertebral body ratio method. Radiology. 1987;164(3):771-5. DOI: 10.1148/radiology.164.3.3615879

View at:

Publisher Site: https://pubs.rsna.org/doi/10.1148/radiology.164.3.3615879

PubMed: https://pubmed.ncbi.nlm.nih.gov/3615879/

Tierney RT, Maldjian C, Mattacola CG, Straub SJ, Sitler MR. Cervical spine stenosis measures in normal subjects. J Athl Train. 2002;37(2):190-3.

View at:

PubMed: https://pubmed.ncbi.nlm.nih.gov/12937434/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC164344/

Rossmeisl JH, Jr. Intervertebral Disk Disease / Veterian Key. Fastest Veterinary Medicine Insight Engine. Chapter 53.

View at:

Publisher Site: https://veteriankey.com/intervertebral-disk-disease

Tjahjadi D, Onibala M Z. Torg ratios based on cervical lateral plain films in normal subjects. Univ Med. 2010;29:8-10.

View at:

Publisher Site: https://univmed.org/ejurnal/index.php/medicina/article/view/213

Scholar: https://www.semanticscholar.org/paper/Torg-ratios-based-on-cervical-lateral-plain-films-Tjahjadi-Onibala/56e7f82cd525d95d435b47c697c9b7a4e93826a6

Stoyanov AN, Vast'yanov RS, Skorobrekha VZ. [Pathophysiological mechanisms of neurovegetology of pain]. Odessa: "Astro-print", 2015. 108 с. [in Russian]

View at:

URL: https://journal.odmu.edu.ua/xmlui/bitstream/handle/123456789/3008/StoyanovPathophysiological.pdf?sequence=1&isAllowed=y

Benato L, Murrell J, Knowles TG, Rooney NJ. Development of the Bristol Rabbit Pain Scale (BRPS): A multidimensional composite pain scale specific to rabbits (Oryctolagus cuniculus). PLoS ONE. 2021; 16(6): e0252417. DOI: 10.1371/journal.pone.0252417

View at:

Publisher Site: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252417

PubMed: https://pubmed.ncbi.nlm.nih.gov/34115781/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195426/

Mathews K, Kronen PW, Lascelles D, Nolan A, Robertson S, Steagall PV, Wright B, Yamashita K. Guidelines for recognition, assessment and treatment of pain: WSAVA Global Pain Council members and co-authors of this document. J Small Anim Pract. 2014 Jun; 55(6):E10-68. DOI: 10.1111/jsap.12200

View at:

Publisher Site: https://onlinelibrary.wiley.com/doi/10.1111/jsap.12200

PubMed: https://pubmed.ncbi.nlm.nih.gov/24841489/

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.