THE ROLE OF OBESITY IN THE DEVELOPMENT OF INFLAMMATION AND PROGRESSION OF HEART FAILURE IN CORONAVIRUS DISEASE
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Keywords

COVID-19, heart failure, obesity

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Samchuk , O., Kapustynska , O., & Sklyarov E.Ya., E. (2022). THE ROLE OF OBESITY IN THE DEVELOPMENT OF INFLAMMATION AND PROGRESSION OF HEART FAILURE IN CORONAVIRUS DISEASE. Medical Science of Ukraine (MSU), 18(1), 8-13. https://doi.org/10.32345/2664-4738.1.2022.02

Abstract

Relevance. Tissue plays a complex physiological role and may therefore progress to COVID-19 and heart failure.

Objective is to evaluate the definition and myocardial biomarkers in a patient with viral disease in combination with obesity and heart failure.

Materials and methods. 89 patients with coronavirus COVID-19 and heart failure were examined. All patients underwent anthropometric measurements and calculation of body mass index, general clinical treatment, levels of reactive protein, ferritin, procalcitonin, interleukin-6, as well as myocardial markers NTproBNP and troponin I.

Results. Among 89 patients, obesity and overweight were diagnosed in 60.7% of cases (41.6% and 19.1%, respectively) and only 39.3% of the weight was in the normal range. Against the background of obesity on COVID-19 pneumonia and heart failure, a statistical increase in the level of C-reactive protein (87.79 ± 16.16 mg / l) was found in patients with COVID-19 pneumonia and non-obesity heart failure (48.79 ± 8.3; mg / l p = 0.036). The statistical value of the level of troponin I (0.04 (0.00; 0.09) on a gas mask in obese patients was noted) (0.01 (0.00; 0.05) ng / ml; p = 0.024).

Conclusion. The growth of C-reactive protein in the body with obesity in pneumonia COVID-19 and heart failure confirms the important role of adipose tissue in induction and maintenance. Ectopic fat depots located in the thickness of the heart may also be involved in the development of inflammatory changes in the myocardium, a laboratory sign that is the growth of troponin I.

https://doi.org/10.32345/2664-4738.1.2022.02
Article PDF (Українська)

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