THE LEVEL OF LEUKOTRIENE B4 IN PATIENTS WITH ARTERIAL HYPERTENSION AND CORONAVIRUS DISEASE
Article PDF (Українська)

Keywords

leukotriene B4, LTB4, coronavirus disease, arterial hypertension, obesity

Abstract views: 96
PDF Downloads: 79

How to Cite

Sklyarova , H., Pokrovska , N., Hrushka , O., & Sklyarov , E. (2022). THE LEVEL OF LEUKOTRIENE B4 IN PATIENTS WITH ARTERIAL HYPERTENSION AND CORONAVIRUS DISEASE. Medical Science of Ukraine (MSU), 18(1), 3-7. https://doi.org/10.32345/2664-4738.1.2022.01

Abstract

Relevance. Patients with comorbid pathology, including arterial hypertension (AH), coronary artery disease, type 2 diabetes, and cerebrovascular disease have been shown to be at risk for coronavirus disease (COVID-19). Currently, among the pathogenetic mechanisms of vascular endothelial damage are considered direct effects of SARS-COV-2 virus, as well as proinflammatory cytokines, which lead to a «cytokine storm» with unpredictable consequences for the patient. In this aspect, the role of leukotriene B4 (LTB4) – one of the first candidates to provoke a hyperimmune inflammatory response in the progression of COVID-19 – was insufficiently elucidated.

Objective: to investigate the level of leukotriene B4 (LTB4) in patients with AH with and without coronavirus disease 2019.

Methods. 78 people with AH and overweight or obesity who were treated at the Lviv Emergency Hospital were examined. All patients were divided into 2 groups: group 1 (n=37) – persons with AH (stage І-ІІІ, grade 1-3); group 2 (n=41) – patients with AH (stage І-ІІІ, grade 1-3), COVID -19 and interstitial lung disease.

Anthropometric measurements with a determination of body mass index (BMI), echocardiography, a blood test, biochemical blood test with determination of glucose, alanine aminotransferase, aspartate aminotransferase, creatinine, and urea were performed. Serum blood samples for the examination of LTB4 (Elabscience Elisa Kit) were taken and processed using ELISA method.

Results. Saturation was significantly lower in patients of group 2, while heart rate and body temperature were higher (p < 0,01) compared to group 1. There was a significant decrease in hemoglobin level, increase in ESR, glucose, and LTB4 in individuals with AH and COVID-19, which is probably due to the presence of inflammation in the lung tissue in coronavirus infection. The concentration of LTB4 ranged from 370 to 3600 pg/l in patients of group 2. 19 individuals (46,3%) of group 2 had a higher level of LTB4 than the median value, which is probably associated with a more severe course of coronavirus infection. A positive correlation between LTB4 and BMI (rs= 0,369; p < 0,05) was found in individuals with AH.

Conclusions. The level of LTB4 is higher in patients with AH and COVID – 19 than in individuals with AH, due to the severity of the inflammation process in this comorbid pathology.

https://doi.org/10.32345/2664-4738.1.2022.01
Article PDF (Українська)

References

Schiffrin EL, Flack JM, Ito S, Muntner P, Webb RC. Hypertension and COVID-19. American Journal of Hypertension. 2020; 33(5):373-374. DOI: 10.1093/AJH/HPAA057

View at:

Publisher Site: https://academic.oup.com/ajh/article/33/5/373/5816609?login=true

PubMed: https://pubmed.ncbi.nlm.nih.gov/32251498/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184512/

Pollard CA, Morran MP, Nestor-Kalinoski AL. The COVID-19 pandemic: a global health crisis. Physiological genomics. 2020; 52(11):549-557. DOI: 10.1152/physiolgenomics.00089.2020

View at:

Publisher Site: https://journals.physiology.org/doi/full/10.1152/physiolgenomics.00089.2020

PubMed: https://pubmed.ncbi.nlm.nih.gov/32991251/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686876/

Beyerstedt S, Casaro EB, Rangel ÉB. COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. European journal of clinical microbiology & infectious diseases. 2021. 40(5):905-919 DOI: 10.1007/S10096-020-04138-6

View at:

Publisher Site: https://link.springer.com/article/10.1007/s10096-020-04138-6

PubMed: https://pubmed.ncbi.nlm.nih.gov/33389262/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778857/

Azevedo RB, Botelho BG, Hollanda JVG de, Ferreira LVL, Junqueira de Andrade LZ, Oei SSML, Mello T de S, Muxfeldt ES. Covid-19 and the cardiovascular system: a comprehensive review. Journal of Human Hypertension. 2021; 35(1):4-11. DOI: 10.1038/S41371-020-0387-4

View at:

Publisher Site: https://www.nature.com/articles/s41371-020-0387-4

PubMed: https://pubmed.ncbi.nlm.nih.gov/32719447/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384729/

Kim JS, Lee JY, Yang JW, Lee KH, Effenberger M, Szpirt W, Kronbichler A, Shin J Il. Immunopathogenesis and treatment of cytokine storm in COVID-19. Theranostics. 2021; 11(1):316-329. DOI: 10.7150/THNO.49713

View at:

Publisher Site: https://www.thno.org/v11p0316.htm

PubMed: https://pubmed.ncbi.nlm.nih.gov/33391477/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681075/

He R, Chen Y, Cai Q. The role of the LTB4-BLT1 axis in health and disease. Pharmacological research. 2020; 158: 104857. DOI: 10.1016/J.PHRS.2020.104857

View at:

Publisher Site: https://www.sciencedirect.com/science/article/abs/pii/S1043661820311658?via%3Dihub

PubMed: https://pubmed.ncbi.nlm.nih.gov/32439596/

Kaka AS, MacDonald R, Greer N, Vela K, Duan-Porter W, Obley A, Wilt TJ. Major update: Remdesivir for adults with covid-19: A living systematic review and meta-analysis for the american college of physicians practice points. Annals of internal medicine. 2021; 174(5):663-672. DOI: 10.7326/M20-8148

View at:

Publisher Site: https://www.acpjournals.org/doi/10.7326/M20-8148

PubMed: https://pubmed.ncbi.nlm.nih.gov/33560863/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901604/

Mbarki M, Sklyarova H, Aksentiychuk K, Kharchenko N, Sklyarov E. Rebamipide and Pantoprazole Combination in NSAIDs-Gastropathy Treatment. Journal of Pharmacy and Pharmacology. 2017; 5(2):153-157. DOI: 10.17265/2328-2150/2017.03.006

View at:

Publisher Site: http://www.davidpublisher.com/index.php/Home/Article/index?id=30138.html

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.