GENE POLYMORPHISM AMONG RESIDENTS OF TERNOPIL REGION AFFLICTED WITH ESSENTIAL ARTERIAL HYPERTENSION
Article PDF (Українська)

Keywords

arterial hypertension, gene polymorphism

Abstract views: 165
PDF Downloads: 99

How to Cite

Hnizdiukh, R., & Shmanko, V. (2021). GENE POLYMORPHISM AMONG RESIDENTS OF TERNOPIL REGION AFFLICTED WITH ESSENTIAL ARTERIAL HYPERTENSION. Medical Science of Ukraine (MSU), 17(4). https://doi.org/10.32345/2664-4738.4.2021.04

Abstract

Relevance. Dissensions in genotype distribution may substantively vary among different ethnic groups; that is why association of particular polymorphous markers with arterial hypertension (AH) development not always matches among distinct populations, which makes researches significant for every ethnic and population group.

Objective is to study prevalence of polymorphism of A1166C-gene of angiotensin II receptor of the first type and T786C-promoter of endothelial NO-synthase gene among patients with arterial hypertension, residents of Ternopil region.

Material and methods. We have examined 86 patients with arterial hypertension who were treated and examined in the therapeutic department of the Central District Hospital in Kozova, aged from 45 to 76 years. The control group consisted of 30 healthy individuals. Genetic typing of endothelial NOS genes and angiotensin II receptors (type 1) genes was performed by means of polymerase chain reaction with electrophoretic scheme of result detection.

Results. When analyzing the frequency distribution of genotypes of polymorphism A1166C of the angiotensin II receptor gene type 1, it was found that the proportion of CC genotype in patients with stage 3 hypertension was 61.1%, which is probably more than in the control group – 16.6% (χ² = 10, 0, p = 0.002). Among patients with stage 2 hypertension, the frequency of AA genotype A1166C polymorphism of the angiotensin II type 1 receptor gene was lower than in the control group (19.1% vs. 43.3%, χ² = 5.2, p = 0.02), and among patients with stage 3 hypertension, the number of individuals with the AA genotype was 11.1% versus 43.3% in the control group (χ² = 5.43, p = 0.02). Analysis of the T-786C polymorphism of the eNOS gene promoter revealed that in patients with stage 2 hypertension, the frequency of pathological CC genotype was higher than in the control group (38.3% vs. 16.6%, χ² = 4.09, p = 0.04 ), patients with stage 3 hypertension also had a greater number of carriers of the CC genotype than in the control group (44.4% vs. 16.6%, χ² = 4.4, p = 0.03).

Conclusions. Results of the research have shown that polymorphism of the type 1 angiotensin II receptors’ A1166C gene and of the eNOS gene T786C-promotor are associated with development of arterial hypertension.

https://doi.org/10.32345/2664-4738.4.2021.04
Article PDF (Українська)

References

Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, ... & Desormais I. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). European heart journal. 2018; 39(33): 3021-3104. DOI: 10.1093/eurheartj/ehy339

View at:

Publisher Site: https://academic.oup.com/eurheartj/article/39/33/3021/5079119

PubMed: https://pubmed.ncbi.nlm.nih.gov/30165516/

Sirenko Yu. M. About new European recommendations on arterial hypertension after their first presentation. Arterial hypertension. 2018. 3(59): 19-22. [in Ukrainian]

View at:

Publisher Site: http://www.mif-ua.com/archive/article/46277

Flack JM, Calhoun D, Schiffrin EL. The new ACC/AHA hypertension guidelines for the prevention, detection, evaluation, and management of high blood pressure in adults. American Journal of Hypertension. 2018; 31(2):133-135. DOI: 10.1093/ajh/hpx207

View at:

Publisher Site: https://academic.oup.com/ajh/article/31/2/133/4706270

PubMed: https://pubmed.ncbi.nlm.nih.gov/29228096/

Savoia C, Burger D, Nishigaki N, Montezano A, Touyz RM. Angiotensin II and the vascular phenotype in hypertension. Expert reviews in molecular medicine. 2011; 13:e11. DOI: 10.1017/S1462399411001815

View at:

Publisher Site: https://www.cambridge.org/core/journals/expert-reviews-in-molecular-medicine/article/abs/angiotensin-ii-and-the-vascular-phenotype-in-hypertension/D8655F93CFC2CD4BDD8FA0629609FBAF

PubMed: https://pubmed.ncbi.nlm.nih.gov/21450123/

Intengan HD, Schiffrin EL. Structure and mechanical properties of resistance arteries in hypertension: role of adhesion molecules and extracellular matrix determinants. Hypertension. 2000; 36(3): 312-318. DOI: 10.1161/01.hyp.36.3.312

View at:

Publisher Site: https://www.ahajournals.org/doi/10.1161/01.HYP.36.3.312

PubMed: https://pubmed.ncbi.nlm.nih.gov/10988257/

Montezano AC, Tsiropoulou S, Dulak-Lis M, Harvey A, Camargo LDL, Touyz RM. Redox signaling, Nox5 and vascular remodeling in hypertension. Current opinion in nephrology and hypertension. 2015; 24(5): 425-33. DOI: 10.1097/MNH.0000000000000153

View at:

Publisher Site: https://journals.lww.com/co-nephrolhypertens/Fulltext/2015/09000/Redox_signaling,_Nox5_and_vascular_remodeling_in.6.aspx

PubMed: https://pubmed.ncbi.nlm.nih.gov/26197203/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727501/

Touyz RM, Schiffrin EL. Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacological reviews. 2000; 52(4): 639-672.

View at:

PubMed: https://pubmed.ncbi.nlm.nih.gov/11121512/

Endemann DH, Schiffrin EL. Endothelial dysfunction. Journal of the American Society of Nephrology. 2004; 15(8): 1983-1992. DOI: 10.1097/01.ASN.0000132474.50966.DA

View at:

Publisher Site: https://jasn.asnjournals.org/content/15/8/1983

PubMed: https://pubmed.ncbi.nlm.nih.gov/15284284/

Butler MG. Pediatric hypertension: genetics of hypertension current status. Journal medical libanais. 2010; 58(3): 175-8.

View at:

PubMed: https://pubmed.ncbi.nlm.nih.gov/21462849/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132177/

Staessen JA, Ginocchio G, Wang JG, Saavedra AP, Soubrier F, Vlietinck R, Fagard R. Genetic variability in the renin-angiotensin system: prevalence of alleles and genotypes. European Journal of Cardiovascular Prevention & Rehabilitation. 1997; 4(5-6): 401-422.

View at:

PubMed: https://pubmed.ncbi.nlm.nih.gov/9865673/

Bonnardeaux A, Davies E, Jeunemaitre X, Fery I, Charru A, Clauser E, ... Soubrier F. Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension. 1994; 24(1): 63-69. DOI: 10.1161/01.hyp.24.1.63

View at:

Publisher Site: https://www.ahajournals.org/doi/10.1161/01.HYP.24.1.63

PubMed: https://pubmed.ncbi.nlm.nih.gov/8021009/

Dosenko VE, Zagoriy VY, Haytovich NV, Gordok OA, Moibenko AA. Allelic polymorphism of endothelial NO-synthase gene and its functional manifestations. Acta Biochimica Polonica. 2006; 53(2): 299-302.

View at:

PubMed: https://pubmed.ncbi.nlm.nih.gov/16733564/

URL: https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.480.4316&rep=rep1&type=pdf

Salimi S, Naghavi A, Firoozrai M, Zand H, Tavilani H, Nakhaee A, Mohebbi A. Association of plasma nitric oxide concentration and endothelial nitric oxide synthase T-786C gene polymorphism in coronary artery disease. Pathophysiology. 2012; 19(3): 157-162. DOI: 10.1016/j.pathophys.2012.04.003

View at:

Publisher Site: https://www.sciencedirect.com/science/article/abs/pii/S0928468012000570?via%3Dihub

PubMed: https://pubmed.ncbi.nlm.nih.gov/22682929/

Niu W, Qi Y. An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension. PLoS One. 2011; 6(9): e24266. DOI: 10.1371/journal.pone.0024266

View at:

Publisher Site: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024266

PubMed: https://pubmed.ncbi.nlm.nih.gov/21912683/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166328/

Paolo Rossi G, Cesari M, Zanchetta M, Colonna S, Maiolino G, Pedon L, ... Pessina AC. The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study. Journal of the American College of Cardiology. 2003; 41(6): 930-937. DOI: 10.1016/S0735-1097(02)03012-7

View at:

Publisher Site: https://www.sciencedirect.com/science/article/pii/S0735109702030127

URL: https://core.ac.uk/download/pdf/82484256.pdf

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.