Relevance.One of the promising methods of treatment of patients with burns is the local use of sorption agents with antimicrobial properties.
Objective: experimental study of antimicrobial properties and clinical evaluation of the effectiveness of local use of a new sorption composition based on nanosilica in the complex treatment of patients with burns.
Materials and methods. The suggested sorption nanocomposition included highly dispersed silicon dioxide, polymethylsiloxane, decamethoxine, metronidazole.
The experimental study involved the study of the antimicrobial properties of the sorption nanocomposition and antimicrobial agents which are part of it.
The clinical material consisted of the results of examination of 42 patients with IIab-III degree burns with an area of 10-30% of the body surface. Depending on the tactics of local treatment, patients were divided into 2 groups: after early necrectomy, xenodermoplasty, the wound surface of the patients in the main group (n = 20) was treated with a solution of decamethoxine in combination with the same sorption powder. Treatment in the comparison group (n = 22) was similar except the use of sorption drugs. The examination included visual inspection of the injured area in combination with microbiological monitoring of the wound contents on the 3rd,7th,14th day.
Results. The obtained results confirmed the sufficient antimicrobial potential of the studied sorption nanocomposition, the properties of which are not inferior to the existing antiseptics for museum and clinical strains of microorganisms and fungi.
Signs of a more favorable wound healing process of the patients in the main group were observed: faster wound cleaning, less inflammatory reactions and much shorter preparation of wounds for grafting.
Conclusions. The obtained results convincingly indicate the effectiveness of a multicomponent composite based on nanosilica with antimicrobial components in a comprehensive treatment of patients with burns.
Rowan MP, Cancio LC, Elster EA, Burmeister DM, Rose LF, Natesan S, Chan RK, Christy RJ, Chung KK. Burn wound healing and treatment: review and advancements. Crit Care. 2015 Jun 12;19:243. DOI: 10.1186/s13054-015-0961-2.
Publisher Site: http://ccforum.com/content/19/1/243
PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464872/
Singh A, Bhatnagar A. Management of Superficial Partial Thickness Burn With Collagen Sheet Dressing Compared With Paraffin Gauze And Silver Sulfadiazine. Ann Burns Fire Disasters. 2020 Sep 30;33(3):233-8.
PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680202/
Nagaichuk VI. [Modern approaches to assistance patients with burns]. State of art technology and medication. 2010;5(71):24-7. [in Ukrainian].
Vigani A, Culler CA. Systemic and Local Management of Burn Wounds. Vet Clin North Am Small Anim Pract. 2017 Nov;47(6):1149-63. DOI: 10.1016/j.cvsm.2017.06.003.
Nielson CB, Duethman NC, Howard JM, Moncure M, Wood JG. Burns: Pathophysiology of Systemic Complications and Current Management. J Burn Care Res. 2017 Jan/Feb;38(1):e469-e481. DOI: 10.1097/BCR.0000000000000355.
Publisher Site: https://academic.oup.com/jbcr/article/38/1/e469/4568966
PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214064/
Elmassry MM, Mudaliar NS, Colmer-Hamood JA, San Francisco MJ, Griswold JA, Dissanaike S, Hamood AN. New markers for sepsis caused by Pseudomonas aeruginosa during burn infection. Metabolomics. 2020 Mar 13;16(3):40. DOI: 10.1007/s11306-020-01658-2.
PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223005/
Jorgensen JH, Ferraro MJ. Antimicrobial susceptibility testing: a review of general principles and contemporary practices. Clin Infect Dis. 2009 Dec 1;49(11):1749-55. DOI: 10.1086/647952.
Publisher Site: https://academic.oup.com/cid/article/49/11/1749/344384
Brook I, Wexler HM, Goldstein EJ. Antianaerobic antimicrobials: spectrum and susceptibility testing. Clin Microbiol Rev. 2013 Jul;26(3):526-46. DOI: 10.1128/CMR.00086-12.
Publisher Site: https://journals.asm.org/doi/10.1128/CMR.00086-12
PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719496/
Shelkova N, Prokopets V. [Quantitative research method of maintenance of bacteria in clinical species which are selected by waddin tampon]. Collection of scientific works of staff member of P.L. Shupyk NMAPE. 2009;17(2):698-702. [in Ukrainian].
Hamblin MR. Novel pharmacotherapy for burn wounds: what are the advancements. Expert Opin Pharmacother. 2019 Feb;20(3):305-321. DOI: 10.1080/14656566.2018.1551880.
PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364296/
Artz CP. Historical aspects of burn management. Surg Clin North Am. 1970;50:1193-200. DOI: 10.1016/s0039-6109(16)39279-9
Lee KC, Joory K, Moiemen NS. History of burns: The past, present and the future. Burns & Trauma. 2014 Oct 25;2(4):169-80. DOI: 10.4103/2321-3868.143620.
PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978094/
Barillo DJ. Topical antimicrobials in burn wound care. A recent history of wounds. Wounds. 2008;20:192-8.
Europe PMC: https://europepmc.org/article/med/25942608
Chernyakova GM, Minukhin VV, Voronin EP, Minukhin DV, Krasnoyaruzskyi AG, Efimov DS, Ponomaryova KV. [Substantiation for antimicrobial efficacy of applicational bionanocomposits in the treatment of the burn infection, caused by S.aureus and P.aeruginosa]. Klinicheskaia khirurgiia. 2017;12:48-51. [in Ukrainian]. DOI: 10.26779/2522-1396.2017.12.48
Publisher Site: https://hirurgiya.com.ua/index.php/journal/article/view/307
Suleimanova VG, Shaprynskyi VO, Kryvetskyi VF, Nasr Zaki Nageeb, Hmelevska TA. Treatment of cervical necrotizing fasciitis, complicated by mediastinitis, on patient with hypoergic immune response. Hospital Surgery. Journal named by L.Ya. Kovalchuk. 2017;1:101-5. [in Ukrainian]. DOI: 10.11603/2414-4533.2017.1.6731
Publisher Site: https://ojs.tdmu.edu.ua/index.php/surgery/article/view/6731
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