CLINICAL AND EPIDEMIOLOGICAL CHARACTERISTICS OF A NEW CORONAVIRUS INFECTION IN THE PRESENT CONDITIONS
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Keywords

coronavirus infection, COVID-19, SARS-CoV-2, adults, clinic

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Moskalyuk , V., Randiuk , Y., Balanyuk , I., & Kolotylo , T. (2021). CLINICAL AND EPIDEMIOLOGICAL CHARACTERISTICS OF A NEW CORONAVIRUS INFECTION IN THE PRESENT CONDITIONS. Medical Science of Ukraine (MSU), 17(2), 90-95. https://doi.org/10.32345/2664-4738.2.2021.13

Abstract

Relevance. In today's world, the attention of health professionals in each country is focused on the outbreak of acute respiratory disease, called coronavirus disease in 2019 - COVID-19. Today there is an increase in the incidence of this disease both in Ukraine and abroad, the disease is more severe, mortality has increased and the percentage of diseases among children has increased.

Objective іs to analyze the clinical and epidemiological features of COVID-19 in Bukovina.

Materials and methods. A retrospective analysis of medical histories of patients with confirmed diagnosis of COVID-19, who were hospitalized in the infectious department of OKNP "Chernivtsi Regional Clinical Hospital".

Results. The age of patients ranged from 22 to 79 years; the average age is 53.6 years. There were 35 men and 30 women (53.8 and 46.2%, respectively). In most patients the course of the disease was moderate, and only 6% of patients had a severe course of the disease. Each hospitalized patient had bronchial and pulmonary lesions, which were confirmed radiologically and by computed tomography (CT). The structure of diagnosed pneumonia was dominated by bilateral lung damage (98.3%). Symptoms of gastrointestinal lesions were noted in 11 patients (16.9%).

Conclusions. According to our observations, we can conclude that susceptibility to a new coronavirus infection is common. However, the elderly, as well as patients with comorbidities, are more likely to develop severe symptoms and higher mortality. Patients at risk with severe course (6%) required special attention. In the early stages of the disease, the use of minimal respiratory support through oxygen therapy is justified.

https://doi.org/10.32345/2664-4738.2.2021.13
Article PDF (Українська)

References

Zadorozhna VI, Vynnyk NP. [Coronavirus 2019-nCOV: new challenges for health and humanity]. Infectious diseases. 2020; 1(99): 5-15. [in Ukrainian]. DOI https://doi.org/10.11603/1681-2727.2020.1

View at:

Publisher site: https://ojs.tdmu.edu.ua/index.php/inf-patol/issue/view/638

A World at risk: Annual report on global preparedness for health emergencies. Global Preparedness Monitoring Board. 2019.

View at:

Publisher site: https://apps.who.int/gpmb/assets/annual_report/GPMB_annualreport_2019.pdf

Chan J.F.-W., Kok K.-H., Zhu Z., Chu H., To K.K.-W., Yuan S., Yuen K.-Y. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerging Microbes & Infections. 2020; 9(1): 221-36. DOI: 10.1080/22221751.2020.1719902

View at:

Publisher site: https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1719902

PubMed: https://pubmed.ncbi.nlm.nih.gov/31987001/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067204/

WHO: New case of laboratory-confirmed SARS in Guangdong, China – update 5. – 31 January 2004.

View at:

Publisher site: https://www.who.int/csr/don/2004_01_31/en/

WHO: MERS situation update. – December 2019.

View at:

Publisher site: http://www.emro.who.int/health-topics/mers-cov/mers-outbreaks.html

WHO: Novel сoronavirus – China (Disease outbreak news: Update 12 January 2020).

View at:

Publisher site: https:// www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/

Zhao S., Musa S.S., Lin Q. Ran J., Yang G, Wang W., Lou Y., Yang L., Gao D., He D., Wang M.H. Estimating the Unreported Number of Novel Coronavirus (2019-nCoV) Cases in China in the First Half of January 2020: A Data-Driven Modelling Analysis of the Early Outbreak. J. Clin. Med. 2020; 9(2):E388. DOI: 10.3390/jcm9020388.

View at:

Publisher site: https://www.mdpi.com/2077-0383/9/2/388

PubMed: https://pubmed.ncbi.nlm.nih.gov/32024089/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074332/

WHO: Novel Coronavirus – Japan (ex-China) (Disease outbreak news: 16 January 2020. Electronic resource.

View at:

Publisher site: https://www.who.int/csr/don/16-january-2020-novel-coronavirus-japan-ex-china/en/

Lu R., Zhao X., Li J. [et al.] Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020 January; 395(10224). DOI: 10.1016/S0140-6736(20)30251-8

View at:

Publisher site: https://www.thelancet.com/article/S0140-6736(20)30251-8/fulltext

URL: https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736%2820%2930251-8.pdf

Guan W., Ni Z., Hu Y. [et al.] Clinical characteristics of 2019 novel coronavirus infection in China. medRxiv. 2020. DOI: 10.1101/2020.02. 06.20020974

View at:

Publisher site: https://www.medrxiv.org/content/10.1101/2020.02.06.20020974v1

URL: https://www.medrxiv.org/content/10.1101/2020.02.06.20020974v1.full.pdf

Europe PMC: https://europepmc.org/article/ppr/ppr112207

Wang D., Hu B., Hu Ch., Zhu F., Liu X., Zhang J., Wang B., Xiang H., Cheng Zh., Xiong Y., Zhao Y., Li Y., Wang X., Peng Zh. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020 Mar 17; 323(11):1061-9. DOI:10.1001/jama.2020.1585

View at:

Publisher site: https://jamanetwork.com/journals/jama/fullarticle/2761044

PubMed: https://pubmed.ncbi.nlm.nih.gov/32031570/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042881/

Huang C., Wang Y., Li X. [et al.] Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395(10223): 497-506. DOI: 10.1016/S0140-6736(20)30183-5

View at:

Publisher site: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext

Zhang H., Kang Z.J., Gong H.Y., Xu D, Wang J, Li Z, Cui X, Xiao J, Meng T, Zhou W, Liu J, Xu H. The digestive system is a potential route of 2019 nCoV infection: a bioinformatics analysis based on single-cell transcriptomes. bioRxiv. 2020. DOI: 10.1101/2020.01.30.927806

View at:

Publisher site: https://www.biorxiv.org/content/10.1101/2020.01.30.927806v1

Holshue M.L., DeBolt C., Lindquist S. [et al.] First case of 2019 novel coronavirus in the United States. N. Engl. J. Med. 2020 Mar 5;382(10):929-36. DOI: 10.1056/NEJMoa2001191.

View at:

Publisher site: https://www.nejm.org/doi/full/10.1056/NEJMoa2001191

https://www.nejm.org/doi/full/10.1056/ NEJMoa2001191#.XjidfXC_qWQ.twitter

PubMed: https://pubmed.ncbi.nlm.nih.gov/32004427/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092802/

Zhao Y., Zhao Z., Wang Y. Zhou Y., Ma Y., Zuo W. Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov. medRxiv. 2020 January 26. DOI: 10.1101/2020.01.26.919985

View at:

Publisher site: https://www.biorxiv.org/content/10.1101/2020.01.26.919985v1

Linton N.M., Kobayashi T., Yang Y., Hayashi K., Akhmetzhanov AR., Jung S-M, Yuan B., Kinoshita R., Nishiura H. Incubation period and other epidemiological characteristics of 2019 novel coronavirus infections with right truncation: A statistical analysis of publicly available case data. J. Clin. Med. 2020; 9(2): 538. DOI: 10.3390/jcm9020538

View at:

Publisher site: https://www.mdpi.com/2077-0383/9/2/538

PubMed: https://pubmed.ncbi.nlm.nih.gov/32079150/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074197/

Backer J.A., Klinkenberg D., Wallinga J. Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20-28 January. Euro Surveill. 2020 Feb; 25(5):2000062. DOI: 10.2807/1560-7917.ES.2020.25.5.2000062

View at:

Publisher site: https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.5.2000062

PubMed: https://pubmed.ncbi.nlm.nih.gov/32046819/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014672/

Tracking coronavirus: Map, data and timeline. BNO Neus. 2020.

View at:

Publisher site: https://bnonews.com/index.php/2020/04/the-latest-coronavirus-cases/

COVID-19 Coronavirus Outbreak. Last updated: February 22, 2020.

View at:

Publisher site: https://www. worldometers.info/coronavirus

Riou J., Althaus C.L. Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020. Euro Surveill. 2020; 25(4):2000058. DOI: 10.2807/1560-7917.ES.2020.25.4.2000058.

View at:

Publisher site: https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.4.2000058

PubMed: https://pubmed.ncbi.nlm.nih.gov/32019669/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001239/

Kampf G., Todt D., Pfaender S., Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. Journal of Hospital Infection. 2020 March; 104(Issue 3): 246-51. DOI: 10.1016/j.jhin.2020.01.022

View at:

Publisher site: https://www.journalofhospitalinfection.com/article/S0195-6701(20)30046-3/fulltext

Scopus: https://www.sciencedirect.com/science/article/abs/pii/S0195670120300463

Agostini M.L., Andres E.L., Sims A.C. [et al.] Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease. mBio. 2018 March; 9(2): e00221-18. DOI: 10.1128/mBio.00221-18.

View at:

Publisher site: https://mbio.asm.org/content/9/2/e00221-18

PubMed: https://pubmed.ncbi.nlm.nih.gov/29511076/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844999/

Beck B.R., Shin B., Choi Y., Park S., Kang K. Predicting commercially available antiviral drugs that may act on the novel coronavirus (2019-nCoV), Wuhan, China through a drug-target interaction deep learning model. bioRxiv. 2020 February. DOI: 10.1101/2020.01.31.929547

View at:

Scopus: https://www.sciencedirect.com/science/article/pii/S2001037020300490?via%3Dihub

Publisher site: https://www.biorxiv.org/content/10.1101/2020.01.31.929547v1

URL: https://www.biorxiv.org/content/10.1101/2020.01.31.929547v1.full.pdf

Jiang S., Du L., Shi Z. An emerging coronavirus caus/ng pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies. Emerging Microbes & Infections. 2020 Jan 31; 9(1): 275-7. DOI: 10.1080/22221751.2020.1723441

View at:

Publisher site: https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1723441

PubMed: https://pubmed.ncbi.nlm.nih.gov/32005086/

PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033706/

Coppo A, Bellani G, Winterton D, [et al]. Feasibility and physiological effects of prone positioning in non-intubated patients with acute respiratory failure due to COVID-19 (PRON-COVID): a prospective cohort study. Lancet Respir Med. 2020; S2213- 2600(20)30268-X. DOI:10.1016/S2213-2600(20)30268-X

View at:

Publisher site: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30268-X/fulltext

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