Relevance. An important issue is predicting the development of complications after surgery for gastric cancer. The most formidable is the failure of the sutures of gastroenteroanastomosis, which in most cases leads to mortality. Therefore, it is important to search for factors and markers to predict the development of these complications. One of the main markers that need to be studied are factors and markers of inflammation.
Objective: to determine of pathophysiological regularities in the development of gastroenteroanastomoses leakage in patients who operated for stomach cancer depends on cryoglobulin level.
Materials and methods. An analysis was carried out without a median result in the treatment of 50 patients, which were promptly operated for stomach cancer with distal subtotal resection of the stomach with the formation of gastroenteroanastomosis from 2013 to 2017. The determination of the blood counts was performed according to the method of A.E. Kalovidoris with modifications. An assessment was made of the number of T-lymphocytes (CD3), and the middle target - T-cytotoxic lymphocytes (CD8), as well as CD4 and CD16 in patients with stomach cancer in the postoperative period.
Results. 6 patients, on the background have had gastroenteroanastomoses leakage. Dynamic monitoring of blood cryoglobulinemia throughout the entire period of surgery in patients with cancer of the gaster, revealing the inadequacy of the concentration of the cryoglobulins. In the peripheral blood of patients, the CD3 + number is significantly reduced (66.2 ± 0.5%, p <0.05).
Conclusions. In such a rank, carried out until the last day, it was established that in patients with cryoglobulinemia that are operated for the stomach cancer, the secondary immune deficiency can form, so that the level of blood cells in the blood is accelerated.
Belous T.A., Litvinova L.V., Pugachev K.K. [Prognostic value of morphological parameters of stomach cancer]. Russian Journal of Oncology. 2007; 2:13-18. [in Russian]
Movchan O.V. [Patterns of microsatellite instability in the development of inflammation in patients with gastric adenocarcinoma]. Dissertation of the candidate of medical sciences. 14.03.04 - pathological physiology. 02/26/2021 [in Ukrainian]
Chang Y.H., Heo Y.J., Cho J., Song S.Y., Lee J., Kim K-M. Computational measurement of tumor immune microenvironment in gastric adenocarcinomas. Sci. Rep. 2018 Sep 17; 8(1):13887. DOI: 10.1038/s41598-018-32299-0.
Publisher site: https://www.nature.com/articles/s41598-018-32299-0
PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141531/
Daniel S.K., Seo Y.D., Pillarisetty V.G. The CXCL12-CXCR4/CXCR7 axis as a mechanism of immune resistance in gastrointestinal malignancies. Semin. Cancer Biology. 2020; 65:1176-188. DOI: 10.1016/j.semcancer.2019.12.007.
Harada K, Lopez A, Shanbhag N., Badgwell B, Baba H, Ajani J. Recent advances in the management of gastric adenocarcinoma patients. F1000Res. 2018 Aug 30; 7:F1000 Faculty Rev-1365. DOI: 10.12688/f1000research.15133.1.
Publisher site: https://f1000research.com/articles/7-1365/v1
PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117861/
Hissong E., Ramrattan G., Zhang P., Zhou X.K., Young G., Klimstra D.S., Shia J., Fernandes H., Yantiss R.K. Gastric Carcinomas With Lymphoid Stroma: An Evaluation of the Histopathologic and Molecular Features. Am J Surg Pathol. 2018; 42(4):463-452. DOI: 10.1097/PAS.0000000000001018.
Huang D., Yang Y., Zhang S., Su Z., Peng T., Wang X., Zhao Y., Li S. Regulatory T-cell density and cytotoxic T lymphocyte density are associated with complete response to neoadjuvant paclitaxel and carboplatin chemoradiotherapy in gastric cancer. Exp. Ther Med. 2018. 16(5):3913-3820. DOI: 10.3892/etm.2018.6684.
Publisher site: https://www.spandidos-publications.com/10.3892/etm.2018.6684
PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176141/
This work is licensed under a Creative Commons Attribution 4.0 International License.