GIPERCRYOGLOBULINEMIA SUCH PATOPHYSIOLOGICAL LINK IN THE POSTOPERATIVE COMLICATIONS FOR STOMACH CANCER PATIENTS
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Keywords

cryoglobulinemia-stomach cancer - gastroenteroanastomoses leakage

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Bagmut, I., Movchan, O., & Gramatiuk , S. (2021). GIPERCRYOGLOBULINEMIA SUCH PATOPHYSIOLOGICAL LINK IN THE POSTOPERATIVE COMLICATIONS FOR STOMACH CANCER PATIENTS. Medical Science of Ukraine (MSU), 17(2), 77-81. https://doi.org/10.32345/2664-4738.2.2021.11

Abstract

Relevance. An important issue is predicting the development of complications after surgery for gastric cancer. The most formidable is the failure of the sutures of gastroenteroanastomosis, which in most cases leads to mortality. Therefore, it is important to search for factors and markers to predict the development of these complications. One of the main markers that need to be studied are factors and markers of inflammation.

Objective: to determine of pathophysiological regularities in the development of gastroenteroanastomoses leakage in patients who operated for stomach cancer depends on cryoglobulin level.

Materials and methods. An analysis was carried out without a median result in the treatment of 50 patients, which were promptly operated for stomach cancer with distal subtotal resection of the stomach with the formation of gastroenteroanastomosis from 2013 to 2017. The determination of the blood counts was performed according to the method of A.E. Kalovidoris with modifications. An assessment was made of the number of T-lymphocytes (CD3), and the middle target - T-cytotoxic lymphocytes (CD8), as well as CD4 and CD16 in patients with stomach cancer in the postoperative period.

Results. 6 patients, on the background have had gastroenteroanastomoses leakage. Dynamic monitoring of blood cryoglobulinemia throughout the entire period of surgery in patients with cancer of the gaster, revealing the inadequacy of the concentration of the cryoglobulins. In the peripheral blood of patients, the CD3 + number is significantly reduced (66.2 ± 0.5%, p <0.05).

Conclusions. In such a rank, carried out until the last day, it was established that in patients with cryoglobulinemia that are operated for the stomach cancer, the secondary immune deficiency can form, so that the level of blood cells in the blood is accelerated.

https://doi.org/10.32345/2664-4738.2.2021.11
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