Relevance. Seasonal differences in stroke incidence are associated with various physical factors, some associated with pathophysiological changes in the body leading to ischemic stroke. At the same time, there is little research into the differences in the frequency of detection of the genome of herpes virus infection and influenza virus, depending on the season.
Objective. Investigate the existence of associations between the season and the frequency of virologically confirmed herpezoid infection manifested by herpezoid virus and influenza virus of patients with ischemic stroke.
Materials and methods. In the period from 01.01.2017 to 31.12.2017. during the year at the bases of the neurological and department of the Alexandrovsky Clinical Hospital Centre. Kyiv conducted a study of 144 cases of cerebral ischemic stroke with the medium-severe neurological deficit: 78 (54.2%) women and 66 (45.8%) men, with an average age of 63.1 0.8 years. Neurological examination and identification of the genome of herpes viruses and influenza virus, performed with the help of a polymerase chain reaction (PCR), was carried out monthly in 12 patients hospitalized by ambulance. The account was taken of the presence of a viral manifestation if it preceded the stroke within 2 weeks.
Results. 36 cases were examined each season. The ratio of men to women was 45.8 / 54.2 in total and did not differ between seasons, p = 0.514. 32 (22.2 percent) patients have demonstrated a viral infection. In winter, 11 (34.4 percent), in spring, 7 (21.9 percent), in summer, 4 (12.5 percent), in autumn, 10 (31.3 percent), and all p. At the same time, during the summer period, the incidence of viral manifestation was definitely lower than in winter, p = 0.042. Virus genomes were found in 12 (33.3 percent) patients in winter, 7 (19.4 percent) in spring, 5 (13.9 percent) in summer, 12 (33.3 percent) in autumn and p = 0.131 rice. During the summer period, the frequency of PCR-confirmed herpes virus infection was definitely lower than in the winter-autumn season, p = 0.033.
Conclusions. Viral manifestations of herpes and influenza virus in the blood are more frequent during the winter and autumn periods; the frequency of detection indicated viral infection from October to January is reliably higher than the rate from March to August inclusive.
In 25.0 percent of patients with ischemic stroke, the genome of herpes viruses and influenza virus in the blood is detected. In the event of a demonstration, the frequency of the above-mentioned viral infection is clearly higher (90.6 percent as against 9.4 percent) than that of patients without it.
2. Flicker L. Cardiovascular risk factors, cerebrovascular disease burden, and healthy brain aging. Clin. Geriatr. Med. 2010 Feb; 26(1): 17-27. DOI: https://doi.org/10.1016/j.cger.2009.12.005
3. G.A. Roth, C.O. Johnson, G. Nguyen, Naghavi M., Feigin V.L., Murray Ch.J.L., Forouzanfar M.H, Vos Th. Methods for estimating the global burden of cerebrovascular diseases. Neuroepidemiology. 2015; 45(3): 146-51. DOI: https://doi.org/10.1159/000441083
4. Forbes HJ, Williamson E, Benjamin L, Breuer J, Brown MM, Langan SM, Minassian C., Smeeth L., Thomas S.L., Warren-Gash Ch. Association of herpesviruses and stroke: Systematic review and meta-analysis. PLoS One. 2018 Nov 21; 13(11):e0206163. DOI: https://doi.org/10.1371/journal.pone.0206163
5. Wu YP, Sun DD, Wang Y, Liu W, Yang J. Herpes Simplex Virus Type 1 and Type 2 Infection Increases Atherosclerosis Risk: Evidence Based on a Meta-Analysis. Biomed Res Int. 2016; 2016: Article ID 2630865. DOI: https://doi.org/10.1155/2016/2630865
6. Liu X.C., Guan Y.M., Hou L., Huang H., Liu H., Li Ch., Zhu Y., Tao X., Wang Q. The Short- and Long-Term Risk of Stroke after Herpes Zoster: AMeta-Analysis. Plos One. 2016 Oct 21. 11(10): e0165203. DOI: https://dx.doi.org/10.1371%2Fjournal.pone.0165203
7. Wang H., Peng G., Bai J.,Не В., Kecheng Н., Нu X., Liu D. Сytomegalovirus Infection and Relative Risk of Cardiovascular Disease (Ischemic Heart Disease, Stroke, and Cardiovascular Death): A Meta‐Analysis of Prospective Studies Up to 2016. Journal of the American Heart Association. 2017 Jul; 6(7): e005025. DOI: https://doi.org/10.1161/JAHA.116.005025
8. Emsley H.C., Smith C.J., Tyrrell P.J., Hopkins S.J. Inflammation in acute ischemic stroke and its relevance to stroke critical care. Neurocrit. Care. 2008; 9(1): 125-38. DOI: https://doi.org/10.1007/s12028-007-9035-x
9. Rupprecht H.J., Blankenberg S., Bickel C., Rippin G., Hafner G., Prellwitz W., Schlumberger W., Meyer J. Impact of viral and bacterial infectious burden on long-term prognosis in patients with coronary artery disease. Circulation. 2001 Jul 3; 104(1): 25-31. DOI: https://doi.org/10.1161/hc2601.091703
10. Worthmann H., Tryc A.B., Deb M., Goldbecker A., Ma Y.T., Tountopoulou A., Lichtinghagen R., Weissenborn K. Linking infection and inflammation in acute ischemic stroke. Ann. NY Acad. Sci. 2010 Oct; 1207: 116-22. DOI: https://doi.org/10.1111/j.1749-6632.2010.05738.x
11. Wang H., Sekine M, Chen X., Kagamimori S. A study of weekly and seasonal variation of stroke onset. Int J Biometeorol. 2002 Dec; 47(1): 13-20. DOI:10.1007/s00484-002-0147-x
12. Palm F., Dos Santos M., Urbanek C., Greulich M., Zimmer K., Safer A., Grau A.J., Becher H. Stroke seasonality associations with subtype, etiology and laboratory results in the Ludwigshafen Stroke Study (LuSSt). Eur J Epidemiol. 2013 May; 28(5):373-81. DOI: https://doi.org/10.1007/s10654-013-9772-4
13. Karagiannis A., Tziomalos K., Mikhailidis P.D., Semertzidis P., Kountana E., Kakafika A.I., Pagourelias E.D., Athyros V.G. Seasonal variation in the occurrence of stroke in Northern Greece: A 10 year study in 8204 patients. Neurological Research. 2010. 32 (3): 326-331. DOI: https://doi.org/10.1179/174313208X331608
14. Warren-Gash C, Blackburn R, Whitaker H, McMenamin J, Hayward AC. Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland. Eur Respir J. 2018 Mar 29; 51(3):1701794. DOI: https://doi.org/10.1183/13993003.01794-2017
15. Esenwa C.C., Elkind M.S. Inflammatory risk factors, biomarkers and associated therapy in ischaemic stroke. Nature Reviews Neurology. 2016 Oct. 12(10):594-604. https://doi.org/10.1038/nrneurol.2016.125
16. Poniatovsky V.A., Bobyr V.V., Shirobokov V.P. [Wastewater treatment from enteroviruses and bacteriophages at the Bortnytska aeration station]. Microbiological Journal. 2014: 76(2): 53-8. [in Ukrainian] URL: http://microbiolj.org.ua/images/files/magazine/2014/2/2014_76_2_09_Ponyatovsky.pdf
17. Odderson I.R. The National Institutes of Health Stroke Scale and its importance in acute stroke management. Phys Med Rehabil Clin N Am. 1999 Nov: 10(4):787-800. PMID: 10573707. URL: https://pubmed.ncbi.nlm.nih.gov/10573707/
18. Kolominsky-Rabas P..L, Weber M., Gefeller O., Neundoerfer B., Heuschmann P.U. Epidemiology of ischemic survival in ischemic strokesubtypes: A population-based study. Stroke. 2001 Dec 1; 32(12):2735-40. DOI: https://doi.org/10.1161/hs1201.100209
19. Emsley H.C., Hopkins S.J. Acute ischaemic stroke and infection: recent and emerging concepts. Lancet Neurol. 2008 Apr; 7(4): 341-53. DOI: https://doi.org/10.1016/s1474-4422(08)70061-9
20. McKnight T.L, Hess D. Climate Zones and Types: The Köppen System. In: Physical Geography: A Landscape Appreciation – Upper Saddle River, NJ: Prentice Hall, 2000. P. 200-201. URL: https://www.worldcat.org/title/physical-geography-a-landscape-appreciation/oclc/43724491
21. Li Y, Zhou Z, Chen N, He L, Zhou M. Seasonal variation in the occurrence of ischemic stroke: A meta-analysis. Environ Geochem Health. 2019 Oct; 41(5): 2113-2130. DOI: https://doi.org/10.1007/s10653-019-00265-y
22. Bogousslavsky J., Kaste M., Olsen T.S., Hacke W., Orgogozo J.M. Risk factors and stroke prevention. European Stroke Initiative (EUSI). Cerebrovasc. Dis. 2000; 10(suppl. 3): 12-21. DOI: https://doi.org/10.1159/000047577
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