RISK FACTORS STUDY OF THREATENED ABORTION OCCURRING IN WOMEN WITH REGARD TO PROGESTERONE RECEPTOR GENE POLYMORPHISM
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Keywords

pregnancy, progesterone receptor gene, threatened abortion, progesterone receptor gene polymorphism, stress

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Kryvopustov, O. (2017). RISK FACTORS STUDY OF THREATENED ABORTION OCCURRING IN WOMEN WITH REGARD TO PROGESTERONE RECEPTOR GENE POLYMORPHISM. Medical Science of Ukraine (MSU), 13(1-2), 21-25. https://doi.org/10.32345/2664-4738.1-2.2017.03

Abstract

Relevance. An important medical and social problem of modern obstetrics is threatening abortion. Among all threatened abortion risk factors today a special attention is given to genetic factors, in particular, to progesterone receptor gene polymorphism. From a progesterone receptor gene polymorphism may depend a progesterone receptor response and a threatened abortion occurring. Determination of the relationship between a progesterone receptor gene polymorphism and miscarriage should be in a priority of modern obstetrics.

Objective: to evaluate risk factors in threatening abortion occurring and a significance of progesterone receptor gene polymorphism among them.

Materials and methods. The study included 197 women at the gestational age of 8-16 weeks., which were divided into 2 groups The first study group consisted of 102 practically healthy pregnant women. The second study group included 95 patients diagnosed with a threatened abortion. The following research methods were used: clinical, questionnaires, laboratory, instrumental, genetic, statistical. In addition to clinical, laboratory, instrumental and statistical research methods, a questionnaire was conducted to determine a stress level and special molecular genetic studies were performed to determine gene polymorphism.

Results. The homozygous carriage of the G-allele by the progesterone receptor gene polymorphism (SNP PGR) rs590688 (p=0,028) and the high stress level by Perceived Stress Scale (p=0,007) are factors that are associated with a high risk of threatened abortion occurring in women. In homozygous G-allele carriers by SNP PGR rs590688 the risk of a threatened abortion occurring is 2.5 times higher than in carriers of other genotypes by this polymorphism (p=0,02).

Conclusion. The most significant risk factors for threatened abortion occurring in women are progesterone receptor gene polymorphism rs590688 and the stress level by the Perceived Stress Scale. The analysis of SNP PGR and a stress level should be used in threatening abortion risk factors evaluation.

https://doi.org/10.32345/2664-4738.1-2.2017.03
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References

Lykhachev V. Praktychne akusherstvo z nevidkladnymy stanamy. Poltava: Medychne informatsiyne ahentstvo, 2010. 720 p. [in Ukrainian].

Al-Asmakh M. Reproductive functions of progesterone. Middle East Fertility Society Journal. 2007. Vol. 12, No. 3. P. 197–201.

Basama F., Crosfill F. The outcome of pregnancies in 182 women with threatened miscarriage. Arch Gynecol Obstet. 2004. No. 270. P. 86-90.

Breiman L. Random Forests. Machine Learning. 2001. No. 45. P. 5–32.

Carp H. Progestogens in the prevention of miscarriage. Horm. Mol. Biol. Clin. Invest. 2015. No. 27. P. 55-62.

Cohen S., Kamarck T., Mermelstein R. Perceived stress scale. Measuring stress: A guide for health and social scientists. 1994.

Guoyang L., Morgan T., Bahtiyar M. Single nucleotide polymorphisms in the human progesterone receptor gene and spontaneous preterm birth. Reprod. Sci. 2008. No. 15. P. 147-155.

Huchon C., Deffieux X., Beucher G. Pregnancy loss: French clinical practice guidelines. Eur J Obstet Gynecol Reprod Biol. 2016. No. 201. P. 18-26.

Kryvopustov O., Dosenko V. Single nucleotide polymorphisms in human progesterone receptor gene and its value in miscarriage or preterm delivery. Fiziol. Zh. 2015. No. 61. P. 111-119.

Ozdemirci S., Karahanoglu E. Influence of threatened miscarriage on pregnancy and early postpartum period: a case-control report. J. Matern. Fetal Neonatal Med. 2015. No. 28. P. 1186-1189.

Practice Committee Opinion of the American Society of Reproductive Medicine. Evaluation and treatment of recurrent pregnancy loss: a committee opinion. Fertil Steril. 2012. No. 98. P. 1103-1111.

Romano A., Delvoux B., Fischer D. The PROGINS polymorphism of the human progesterone receptor diminishes the response to progesterone. J. Mol. Endocrinol. 2007. No. 38. P. 331-350.

Su M., Lee I., Chen Y. Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population. J. Assist. Reprod Genet. 2011. No. 28. P. 239-243.

Wahabi H., Abed A. Progestogen for treating threatened miscarriage. Cochrane Database Syst Rev. 2011.

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