Article PDF


tissue engineering; bone tissue defects; scaffold; cells

Abstract views: 164
PDF Downloads: 187

How to Cite

Chumachenko, O., Topchii, D., Gromovy, U., & Plyatsko, S. (2019). SCAFOLDS IN PERIODONTAL SURGERY. Review. Medical Science of Ukraine (MSU), 15(1-2), 87-92.


Relevance. Substitution of bone defects in destructive periodontitis is one of the most difficult tasks of maxillofacial surgery. Today, tissue engineering, which makes up the classical triad: biomaterials + cells + growth factors, is the most effective and technologically promising for restoring the parameters and structure of the alveolar bone.

Objective. The goal is to summarize  of literature data on the possibilities of using modified scaffold materials, bone morphogenetic proteins, growth factors in tissue engineering in the replacement of jaw bone defects.

Materials and methods.Scientific literature search was carry out using scientometric bases such as Scopus, PubMed, Web of Science, RSCI during 18 years (2001-2018). The literature sources on the possibility of using osteoinductive and osteoconductive materials in dentistry is analyzed. Also the data on the possibility and prospects of using individual osteoregenerative drugs for periodontal diseases and for the elimination of jaw defects was analyzed. The characteristics of the composition, properties, manufacturing methods and mechanism of action of osteoplastic materials was analyzed.

Results. Advantages of osteoreparative technologies using scaffolds are their sufficient hydrophilicity, the possibility of complete biocompatibility, biodegradation of the material without any toxic effects on the patient’s body, the possibility of penetration into the cell structure and different molecular sizes (including those stimulating angiogenesis), maintaining the required volume, the possibility of programming the composition and properties at the manufacturing stage and the like. Tissue-engineering constructs have shown their high mechanical and biological properties for osteogenic differentiation and cell replacement. In addition, it is possible to expand operational protocols depending on the specific anatomical and physiological conditions in each patient.

Conclusion. The use of modified scaffold materials, bone morphogenetic proteins, growth factors in tissue engineering allows us to restore the structure and volume when replacing defects in the bone tissue of the jaw. Tissue engineering (matrices, growth factors, cells) is becoming an attractive clinical approach for bone regeneration.
Article PDF


Volkov A.V. Morphology of reparative osteogenesis and osseointegration in maxillofacial surgery / Diss. dok. M. 2018. 261s [Russian]

Volkov N.M., Physiology of bone metabolism and the mechanism of development of bone metastases // Practical oncology. 2011; 3: 97-102. [Russian]

Onopriyenko G.A., Voloshin V.P. Modern concepts of physiological and reparative osteogenesis // Almanac of clinical medicine. 2017; 45 (2): 79-93.

Paraskevich V.L. Dental implantology. Fundamentals of theory and practice. 2nd ed. / M.: Medical news agency, 2006. 400 s.

Alsberg E., Hill E.E., Mooney D.J. Craniofacial tissueengineering // Crit Rev Oral Biol Med. 2001; 12 (1): 64-75. DOI: 10.1177/10454411010120010501

Amoabediny Gh., Salehi-Nik N., Heli B. The role of biodegradable engineered scaffold in tissue engineering. In: Biomaterials Science and Engineering / Ed. by Pignatello R. InTech. 2011; p.153-172.

Anitua E., Sanchez M., Orive G., Andia I. Shedding light in the controversial terminology for platelet rich products // J Biomed Mater Res. 2009; 90 (4): 1262-3. DOI: 10.1002/jbm.a.32143

Karageorgiou V., Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis // Biomaterials. 2005; 26 (27): 5474-91. DOI: 10.1016/j.biomaterials.2005.02.002

Kim K., Dean D., Mikos A.G., Fisher J.P. Effect of initial cell seeding density on early osteogenic signal expression of rat bone marrow stromal cells cultured on crosslinked poly (propylene fumarate) disks // Biomacromolecules. 2009; 10 (7): 1810-7. DOI: 10.1021/bm900240k.

Klenke F.M., Liu Y., Yuan H., Hunziker E.B,. Siebenrock K.A., Hofstetter W. Impact of pore size on the vascularization and osseointegration of ceramic bone substitutes in vivo // J Biomed MaterRes A. 2008; 85 (3): 777-86. DOI: 10.1002/jbm.a.31559

Mirzatolooei F., Alamdari M.T., Khalkhali H.R. The impact of platelet-rich plasma on the prevention of tunnel widening in anterior cruciate ligament reconstruction using quadrupled autologous hamstring tendon: A randomised clinical trial // Bone Joint J. 2013; 95-B (1): 65-9. DOI: 10.1302/0301-620X.95B1.30487.

Murphy C.M., Haugh M.G., O’Brien F.J. The effect of mean pore size on cell attachment, proliferation and migration in collagen–glycosaminoglycan scaffolds for bone tissue engineering // Biomaterials. 2010; 31 (3): 461-6. DOI: 10.1016/j.biomaterials.2009.09.063.

Uebersax L., Hagenmuller H., Hofmann S., Gruenblatt E., Müller R., Vunjak-Novakovic G., Kaplan D.L., Merkle H.P., Meinel L. Effect of scaffold design on bone morphology in vitro // Tissue Eng. 2006; 12 (12): 3417-29. DOI:


Volkmer E., Drosse I., Otto S., Stangelmayer A., Stengele M., Kallukalam B.C., Mutschler W., Schieker M. Hypoxia in static and dynamic 3D culture systems for tissue engineering of bone // Tissue Eng Part A. 2008; 14 (8): 1331-40. DOI: 10.1089/ten.tea.2007.0231.

Yang S., Leong K.F., Du Z., Chua C.K. The design of scaffolds for use in tissue engineering. Part I. Traditional factors // Tissue Eng. 2001; 7 (6): 679-89.

DOI: 10.1089/107632701753337645

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.