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adult cystic fibrosis, radiology, computed tomography

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Morozova, N., Tkachenko, M., & Romanenko, A. (2019). RADIOLOGIC DIAGNOSTIC’S CAPABILITIES OF LUNG INJURY IN ADULT PATIENTS WITH CYSTIC FIBROSIS. Medical Science of Ukraine (MSU), 15(1-2), 51-58.


Relevance. The viability of patients is determined by the degree of lung injury despite the fact that cystic fibrosis (CF) is a multiple organ disease. Early diagnosis and adequate treatment complex of cystic fibrosis prolong the lives of patients and improves its quality. Therefore, timely and detailed diagnosis of cystic fibrosis lung is particularly important problem. The central role for its solution belongs to radiological studies.    

Objective. To refine the radiology’s capabilities in detecting lung changes in case of cystic fibrosis in adult patients and to determine the role of the computed tomography (CT) in the diagnostic process.

Materials and methods. The results of radiography and CT scans of 15 patients, for whom the diagnosis of CF was established in adulthood, were analyzed.

Results. The most typical radiographic and CT signs of lung damage were determined in adult CF patients. It has been shown that the radiographic changes in the lungs are non-specific for CF patients and are determined by the secondary inflammatory process. The diagnostic capabilities of CT scans in detecting subtle structural changes in the lung tissue and bronchial tree are underlined, which allows to diagnose light and atypical forms of CF in adults, determinate the stage and activity of the pathological process and the effectiveness of the treatment.

Findings. The radiation studies were able to define the CF’s specific symptoms of lung lesions. Radiography of the thoracic cavity’s organs is a necessary step in the preliminary diagnosis for adult patients with CF or in the medical emergency's cases. The CT has the greatest diagnostic value in detecting subtle structural and functional specific changes of CF. The regular monitoring using CT scans is necessary for improving the control of the respiratory organs’ state and determine the further tactics for the particular patient.
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Bowmer G., Sowerby C., Duff A. Transition and transfer of young people with cystic fibrosis to adult care // Nursing Children and Young People. 2018; 30 (5): 34-9. DOI: 10.7748/ncyp.2018.e1080.

Characteristics of cystic fibrosis in adolescents / Kondratyev E.I., Kapranov N.I., Krasovsky S.A., Kashirskaya N.Yu., Sherman V.D., Nikonova V.S. / Cystic fibrosis: new challenges, new solutions / Abstracts of the XI National Congress «Cystic fibrosis in children and adults. A look into the future», May 24-25, 2013. Vol. 1. P. 34-36.

Cholon D.M., Quinney N.L., Fulcher M.L., Esther CR Jr, Das J, Dokholyan NV, Randell SH, Boucher RC, Gentzsch M. Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis // Sci Transl Med. 2014; 6 (246): 246ra96. DOI: 10.1126/scitranslmed.3008680.

Krasovsky S.A., Samoilenko V.A., Ameline E.L. Cystic fibrosis: diagnosis, clinic, basic principles of therapy // Pulmonology and allergology. 2013; 1: 42-6.

Leonard H.T., Jain, Manu. Diagnosis of Cystic Fibrosis in Adults // Clinical Pulmonary Medicine. 2012; 19 (Issue 4): 159-64. DOI: 10.1097/CPM.0b013e31825d5c5d

Lyczak J.B., Cannon C.L., Pier G.B. Lung Infections Associated with Cystic Fibrosis // Clin Microbiol Rev. 2002; 15 (2): 194-222. DOI: 10.1128/CMR.15.2.194-222.2002

Gilljam M, Ellis L, Corey M, Zielenski J, Durie P, Tullis DE. Clinical manifestations of cystic fibrosis among patients with diagnosis in adulthood // Chest 2004;126 (4):1215-24. DOI: 10.1378/chest.126.4.1215

Golubtsova O.I., Dianova T.I., Krasnov M.V., Safonov D.V., Krasovsky S.A., Egorova I.N. Modern opportunities for diagnosing lesions of the bronchopulmonary system in cystic fibrosis in children // Modern problems of science and education. 2016; 3: 76-9.

Kapranov N.I., Kashirskaya N.Yu. Cystic fibrosis. M.: Medical practice, 2014. P. 248-70.

Maloletnikova I. M. Reasons for the late diagnosis of cystic fibrosis / I. M. Maloletnikova, A. I. Zaryankina, Yu. Yu. Abdullina // Problems of Health and Ecology. 2016; 4 (50): 93-5.

McWilliams TJ, Wilsher ML, Kolbe J. Cystic fibrosis diagnosed in adult patients // N Z Med J. 2000; 113 (1102): 6-8. PMID: 10738492

Burns JL, Emerson J, Stapp JR, Yim DL, Krzewinski J, Louden L, Ramsey BW, Clausen CR. Microbiology of sputum from patients at cystic fibrosis centers in the United States // Clin. Infect. Dis. 1998; 27 (1): 158-63. DOI: 10.1086/514631

Okumura MJ, Kleinhenz ME. Cystic Fibrosis Transitions of Care: Lessons Learned and Future Directions for Cystic Fibrosis // Clin Chest Med. 2016; 37 (1): 119-26. DOI: 10.1016/j.ccm.2015.11.007.

Phuan PW, Veit G, Tan JA, Finkbeiner WE, Lukacs GL, Verkman AS. Potentiators of Defective ΔF508-CFTR Gating that Do Not Interfere with Corrector Action // Mol Pharmacol. 2015; 88 (4): 791-9. DOI: 10.1124/mol.115.099689.

Paschoal IA, de Oliveira Villalba W, Bertuzzo CS, Cerqueira EM, Pereira MC. Cystic fibrosis in adults // Lung. 2007; 185 (2): 81-7. DOI: 10.1007/s00408-006-2597-0.

Raksha Jain. Diagnosing Cystic Fibrosis in Adults: Better Late Than Never // Ann Am Thorac Soc. 2018; 15 (10): 1140-41. doi: 10.1513/AnnalsATS.201806-432ED.

Ramsey BW, Davies J, McElvaney NG, Tullis E, Bell SC, Dřevínek P, Griese M, McKone EF, Wainwright CE, Konstan MW, Moss R, Ratjen F, Sermet-Gaudelus I, Rowe SM, Dong Q, Rodriguez S, Yen K, Ordoñez C, Elborn JS. A CFTR potentiator in patients with cystic fibrosis and the G551D mutation // N Engl J Med. 2011; 365 (18): 1663-72. doi: 10.1056/NEJMoa1105185.

Heeley M.E., Woolf D.A., Heeley A.F. Indirect measurements of sweat electrolyte concentration in the laboratory diagnosis of cystic fibrosis // Arch. Dis. Child. 2000. 82 (5): 420-4. DOI: 10.1136/adc.82.5.420

Yankaskas JR, Marshall BC, Sufian B, Simon RH, Rodman D. Cystic fibrosis adult care: consensus conference report // Chest. 2004; 125 (1 Suppl): 1S-39S. 54. DOI: 10.1378/chest.125.1_suppl.1s

Widerman E, Millner L, Sexauer W, Fiel S. Health status and sociodemographic characteristics of adults receiving a cystic fibrosis diagnosis after age 18 years // Chest. 2000; 118 (2): 427-33. DOI: 10.1378/chest.118.2.427.

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