Relevance. Practically 10-15 % of the world's population has varicose veins as a manifestation of chronic venous insufficiency. The clinical and genealogical method is the method allows to identify family cases of disease in patients with chronic venous insufficiency.
Objective: to demonstrate the role of heredity in varicose disease, to analyze family cases of varicose disease, to determine the type of disease inheritance and to give a prediction of heredity for descendants, using the clinical and genealogical method.
Materials and methods. The study involved 72 patients, mostly women – 46 (63.9 %) persons, with different classes of varicose veins according to the CEAP classification. To determine the type of inheritance we used clinical and genealogical method of pedigrees’ study. The nature of the trait – hereditary or non-hereditary disease; type of the inheritance – autosomal-dominant, autosomal-recessive, sex-linked, were defined.
Results. The family nature of the varicose disease was revealed in 17 (23 %) of the 72 examined patients. The autosomal-dominant type of inheritance was determined. There is direct inheritance across generations.
Conclusions. We determined the family nature of the disease inheritance, with the autosomal-dominant type of inheritance with a high degree of gene expression. In these families there is a high risk of the birth of the children who will have chronic venous insufficiency.
Amato B., Coretti G., Compagna R. Role of matrix metalloproteinases in non-healing venous ulcers // Int. Wound J. 2015. 12 (6). 641-645. https://doi.org/10.1111/iwj.12181
Dzieciuchowicz L., Espinosa G., Paramo J.A. Increased Levels of Metalloproteinase 10 and Hemostatic Markers in Patients With Noncomplicated Primary Varicose Veins // Clin. Appl. Thromb. Hemost. 2015. 21 (5). 684-687. https://doi.org/10.1177/1076029613517167
King J.T., O’Byrne M., Vasquez M, Treatment of Truncal Incompetence and Varicose Veins with a Single Administration of a New Polidocanol Endovenous Microfoam Preparation Improves Symptoms and Appearance // Eur. J. Vasc. Endovasc. Surg. 2015. 50 (6). 784-793. https://doi.org/10.1016/j.ejvs.2015.06.111
Lee S., Lee W., Choe Y. Gene expression profiles in varicose veins using complementary DNA microarray // Dermatol. Surg. 2005. 31 (4). 391-395. https://doi.org/10.1111/j.1524-4725.2005.31103
MacColl E., Khalil R.A. Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Disease // J. Pharmacol. Exp. Ther. 2015. 355 (3). 410-428. https://doi.org/10.1124/jpet.115.227330
Ng M.Y., Andrew T., Spector T.D., Jeffery S. Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs // J. Med. Genet. 2005. 42 (3). 235-239. https://doi.org/10.1136/jmg.2004.024075
Rabe E., Pannier F. Epidemiology of chronic venous disorders / Handbook of Venous and Lymphatic Disorders / CRC Press. 2016. 121-127. http://dx.doi.org/10.1201/9781315382449-12
Serra R., Buffone G., de Franciscis A., A genetic study of chronic venous insufficiency // Ann. Vasc. Surg. 2012. 26 (5). 636-642. https://doi.org/10.1016/j.avsg.2011.11.036
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