MODERN TRENDS OF MEDICAL NEPHROPROTECTION IN TYPE 1 DIABETES MELLITUS
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Keywords

type 1 diabetes mellitus, diabetic nephropathy, oxidative stress, pharmacological nephroprotection

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Khaitovych, M., & Ivchenko, M. (2017). MODERN TRENDS OF MEDICAL NEPHROPROTECTION IN TYPE 1 DIABETES MELLITUS. Medical Science of Ukraine (MSU), 12(3-4), 122-128. Retrieved from https://msu-journal.com/index.php/journal/article/view/100

Abstract

Resume. Type 1 diabetes mellitus is one of the widespread endocrinological diseases in the world that has a stable growth dynamics. Diabetes mellitus is characterized by the development of severe disabling complications, including diabetic kidney disease (diabetic nephropathy) is one of the most dangerous.

The pathogenesis of diabetic nephropathy comprehensive and includes the following components: hereditary, metabolic (hyperglycemia, hyperlipidemia, hyperuricemia), hemodynamic (intraglomerular hypertension, arterial hypertension), hormonal (hyperinsulinemia, activation of the renin-angiotensin-aldosterone system), immune (imbalance in the production of pro- and anti-inflammatory cytokines, growth factors, etc.) violations.

In many tissues hyperglycemia leads to the generation of free radicals. In the absence of adequate compensatory response by the endogenous antioxidant system in the body oxidative imbalance occurs leading to activation of stress-sensitive signaling pathways involving transcriptional factor NF-kB, mitogen-activated protein kinase, protein kinase C. The result is the synthesis of gene products causing cell injury, inflammation and apoptosis, which eventually leads to the development of late diabetic complications.

Lately, the nephroprotective properties of variable antioxidant compounds of nature and synthetic origin (including bioflavonoids, vitamin D3, ibuprofen, N-acetylcysteine etc.) for complex treatment of type 1 diabetes mellitus and its complications (especially diabetic nephropathy) has been actively discussed.

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